I have two friends who were recently diagnosed with depression. They were both prescribed Prozac by their respective doctors. Both of them are heavy marijuana users and both failed to mention that to their doctors. One has been on Prozac for two months and the other for six weeks. I have noticed that their behavior has become strange: mood swings, paranoia, oversleeping, fatigue. They continue taking their Prozac (20 mg a day) and continue smoking pot. I am afraid that there might be some negative interaction between the substances, one being an antidepressant and the other a depressant. Can you provide some insight?

I'm curious about drugs — in particular what happens when you chemically combine methamphetamine and PCP and how it might affect the body. Some places online say they're the same thing, but I'm not so sure.

My friend recently smoked some pot laced with cocaine. First of all, is this possible? Whatever the case may be, he seems to be infatuated with the idea of trying straight coke. I've heard that trying coke for the first time is quite dangerous, true? Also, what are the effects of the high? And how detrimental is coke in general?

I'm a college student who is struggling with the decision on when to see a doctor for treatment with my depression symptoms. I believe that I need to get treated for depression, but I'm just as scared about not getting treatment as I am about starting antidepressant drugs in my current lifestyle. As far as I can tell, I'm exhibiting the classic symptoms of depression, and have been for a while — frequent crying fits, days where I lose all motivation, and sometimes, even thoughts of suicide. But I drink frequently, almost every weekend, and use marijuana occasionally, and I am quite unsettled by the possible interactions between antidepressants and these other substances. In my day to day life I do very well — I hold a good GPA, have good relationships and a good social life, function well most of the time, and stay in shape for sports. I don't intend to change my lifestyle significantly to make room for depression treatment. But when do I need to get help? I don't want to force an unnecessary change on myself, but I don't want to put myself in danger from depression, or even worse, from the drug interactions between antidepressants and alcohol or weed. What is the tipping point?

I have ADHD and am prescribed 30 mg of Ritalin a day. However I also smoke pot at least once a week. Is it okay to be smoking while on Ritalin?

Me and my friends are users of X. We know that it's illegal and not good for you, but it's only a once in a while thing. My question is that I know there are different types of X pills that you can take. We have been getting motorolas and I know a friend told me that mitsubishis are really bad to take. I was wondering the differences between the pills and the differences between triple and double stacked pills......

Many of my friends take Adderall while they drink. What are the possible health risks of doing this? I know Adderall is a stimulant, so can you drink much more alcohol while on it without feeling the effects as much?

Are the health risks of drinking Red Bull and vodka in moderation (two to three) drinks an evening any greater than drinking two or three rum and Cokes, or two or three anything and Mountain Dew?

Is it ok to drink alcohol while taking Xanax?