1) I have a large amount of course work, which is combined with a job and extra-curriculars, and while I want to succeed in all of them, I find that I simply don't have enough time, even though I currently sleep only 4 or 5 hours a night. I mentioned this to a group of my friends here at school, and it turns out they all take stimulants to help them manage jam-packed undergraduate life. The pills are called ADDERALL and PROVIGIL. I have acquired some for myself, but before I take them, could you tell me if either has serious health risks? I do not have any other health problems or take any other medications. A few of my friends tell me that they sometimes stay awake for as long as 3 or 4 days. If it is reasonably safe, that would be great! Thank you.

2) Given the fact that this is a top-notch school, it's total hoo-ha that you haven't included any info on all the non-hard core, but still illegal, "study stimulants." Is all this ADDERALL gonna do me permanent damage or what?

Does acid (LSD) have a detrimental affect on women who use the birth control pill? Is it possible for a woman to be impregnated by pre-ejaculatory fluids four days after the menstrual cycle after unprotected sex?

I have a history of "experimentation" (infrequent or occasional use of ecstasy, 'shrooms, and other drugs — mostly prescription pills). I am completely sober now, but am worried about long-term damage to my brain. I used drugs infrequently (no more than three to five times for each substance), but drank regularly. How worried should I be? Is there anything I can do to combat long-term effects?

Recently, I have heard about a new hallucinogen available called salvia dinorium. Some of my friends have tried it and they tell me it is an incredible experience and that when you hallucinate, you have the perception of being brought back in time. Before I even think about trying this, however, I would like to have a more precise idea of what the effects are and what the possible risks of taking salvia are.

I have been reading some studies that state a correlation between the "religious experience" generated by the psilocybin in magic mushrooms and LSD, and an alleviation of body dysmorphic, obsessive compulsive, and other related disorders. I was wondering if this is anything being pursued, whether these effects have been proven, and how long the symptoms are alleviated for if this is the case. Are there any specific conditions that must be met in order to avoid a "bad trip"? I know people experiencing any kind of mood disorder are succeptable as such.

I have heard that people can become trapped in their own world of hallucinations permanently from taking 'shrooms, acid, or other hallucinogens and have to live in a mental health facility because they are so out of touch with reality. I'm wondering is this true? And if so what is this medical condition called? I've heard of Hppd, but what I have read about it, it doesn't sound exactly the same. I'm also curious what the likelihood of this happening would be and if it is dependent on the use of many drugs, dosage, or the user's mental state or other preexisting health conditions that could affect this. I'm really hoping you can answer this question because I haven't found any reliable sources about this topic.

Thanks so much!

1) I have two friends who I think are drinking too much. I don't know what to do. They are very defensive should anyone say anything to them about their excessive habit, and a lot of our friends are giving up on them. This has become a daily thing and their schoolwork and friendships are all suffering. They are both 21; one recently broke up with his girlfriend of several years and the other has been single for a while and he hates it. I know that has a lot to do with it. Please suggest some non-intrusive ways to help them. I'm really at a loss.

2) Last year, I became very good friends with a guy on my floor. He was a little out of the ordinary in the way he dressed, as well as in some of his opinions and habits. I had the feeling that he did drink more than he should, and he also did pot. I did not worry too much about it because it appeared to be more of a lifestyle choice than an addiction, and it did not cause him major troubles.

Unfortunately, he started to have academic problems. He did not do his work, missed classes, and eventually exams as well. I still did not relate these things to his alcohol and drug habits, and I hoped that once he got over the adjustment everyone needed to make in freshman year, he would be fine. Well, he wasn't. He did not come back to school this fall, and when I called him, I learned that he had gone through a lot that summer. He was diagnosed with depression and a cocaine addiction, put on Prozac, and sent to therapy. At that point, I thought that he was on the right track because he was also going to get a job and planning to take classes at a nearby college.

However, when he came to visit me a month later, he had already had two beers before he even came here and got more and more drunk as the evening progressed. I would not let him drive home, but he ignored my warnings and left anyway. I was very disturbed because a friend of his had just been in a drunk driving accident. I was very mad at him, told him clearly that I will always be his friend but prefer not to talk to him or see him if he showed up drunk again. He did not call for a while and neither did I. When he called me yesterday and I told him that I thought he should do something about his alcohol problem, he kept repeating his excuses, that he drinks because he is Irish, that he doesn't care if he dies early as long as he had fun in life, etc. On the other hand, he can't find a job and seems to be very depressed. I want to help him, but I don't know how. Any ideas?

I have been doing weed for about six months now and on occasion a few other drugs. I usually do it only on average three times a week and a lot more on the weekends. I feel that it is ruining my life because my concentration is terrible and my marks have dropped significantly (20 points). I feel like I'm in a dream all the time and it just isn't fun anymore. I have heard that pot is not addictive but I have tried to stop but I feel sick and irritable if I don't smoke up. I have realized I need to quit but I can't. Why can't I stop if this "soft drug" is not addictive? Am I crazy? Please help. I want my life back. Thank you so much.

I have never had a problem with alcohol tolerances in the past. I could drink at least four or five drinks and be fine that night and the next morning. Now, I find myself getting violently sick after drinking just one or two. Even after a glass of wine I want to puke it up. Is there something physically wrong with me? I know the obvious solution is to stop drinking entirely. But, I shouldn't be this sick after drinking just one drink. Have you ever heard of this before? Can you help me figure out the problem?

My granddad has been an alcoholic for ages — way before I was born. I am really worried about my granddad’s drinking. My father doesn't like me to see him when he is drunk, but that is kind of hard. What are the best groups for alcoholics? And most importantly, what should I do?

My uncle shoots heroin. My father used to do cocaine. My moms' (both of them) used to smoke weed with their friends when I was eight. I smoked weed when I was twelve. I sold weed at 14.

I don't want to continue in the vein of my addictive family (no pun intended). How hereditary is addiction? What measures can I take to avoid falling into the same hazy trap of my family members?

On "big nights out" (about once a month) friends of mine "plug" ecstasy tablets — by which I mean they each stick one up their butt instead of swallowing.

They claim that is a "safer" way to ingest E because it bypasses the liver and goes right into the bloodstream. They also claim the effects are heightened.

I have been tempted to try this method as they swear by it, but thought I'd get your opinion first — are there any potential side effects to plugging? Is it really a "safer" way to use E?

I am curious about the effectiveness of ketamine for therapy and recovery of drug use in young people/teenager in depression and success rate.

Is lsd safe to use while on an SSRI.

1) Are there any adult children of alcoholics groups on campus?

2) My father is an alcoholic and I've been told that I should stay away from drinking altogether. I'm a freshman this year and it seems like most of my friends always want to go to keg parties or hang out and drink. Sometimes I drink with them, but then I feel guilty and worried afterwards as I think about my dad. It's hard to avoid alcohol here, but I don't want to follow in my father's footsteps either. Any advice or support you can give would help. Thanks.

My boyfriend is on steroids. He injects them through his rear end. I have seen no negative signs of this but I have read about them and I am worried that extended use of this drug will lead to serious problems, emotional and physical. I have told him about the problems steroids cause, but he doesn't think it will happen to him. What could I do to stop his use?

I think it would be a good idea for me to stop smoking marijuana and cut down on my drinking, at least during the school year. The problem is, I have been doing it for so long it is almost as though I have forgotten how to have fun without it. Contributing to this problem is the fact that many of my friends smoke or drink to have fun. Many of my other friends just do not seem to have fun at all; they stay in Friday and Saturday nights to do work. I've found it difficult to quit, I think because I'm just not sure of what's out there to do that's fun without being stoned or drunk. Can you recommend anything that's fun whether you're intoxicated or sober, so that I don't have to stop hanging out with certain friends if I want to relax and have fun? I want to finally enjoy life without relying on an altered state of consciousness. What's there to do when you're sick of renting movies? Also, any tips for resisting the urge to take people up on their offer to toke up? (I'm never pressured into it, but it's like the dieter who's offered some chocolate cake — it's there, it looks sooo good, and the fact that other people are doing it makes it seem more "okay.") Thanks so much.

What are the effects of sniffing lighter fluid? I recently had a friend sit in a car to listen to music and smell lighter fluid. He tells me he gets a high from this. What are the effects of doing this? I would appreciate this to educate my friend.

I have two friends who were recently diagnosed with depression. They were both prescribed Prozac by their respective doctors. Both of them are heavy marijuana users and both failed to mention that to their doctors. One has been on Prozac for two months and the other for six weeks. I have noticed that their behavior has become strange: mood swings, paranoia, oversleeping, fatigue. They continue taking their Prozac (20 mg a day) and continue smoking pot. I am afraid that there might be some negative interaction between the substances, one being an antidepressant and the other a depressant. Can you provide some insight?

1) I am wondering about the direct effects nitrous oxide has on the brain, and if it is a fallacy that it kills brain cells.

2) What are the health dangers of inhaling nitrous oxide? I have heard people say that it "kills brain cells," but no one seems to know how, to what extent, and what the resulting effects are. Since nitrous oxide is commonly administered as anesthesia, is there a safe way to consume it for recreational use? If the user controls her oxygen intake, do the harmful effects (if any) still occur?

I have a friend at school who quit smoking last year in January, and went back to it in October. I have no idea why, and he also started doing other drugs, such as smoking blunts, doing ecstasy, and taking steroids. The drug that I am worried about him doing the most is ecstasy, because it's a dangerous drug. Also, he is always talking about doing drugs. How can I help him? I still want him to be my friend. Please help. This is serious.

Lately, I have been doing a drug called Special K. I know it is a sedative/tranquilizer (what's the difference?), but very little about side effects, etc. Also, can you go over similar information about the drug X?

I have a huge dilemma. I have an addiction to a certain drug that has turned my life upside down. That drug is crack cocaine. The worst part about it is that nobody knows this but me. Nobody knows that right now, my life is on the brink. How do you express this problem to people who don't even have a clue as to what you are dealing with? How do you reach out to the people who you love and trust when you are so ashamed of the truth? One thing that I do know is that I'd better do something fast because if I don't, I will lose my fight with life. HELP!!

I have been trying to find information about the hope for recovery for previous meth users, but there doesn't seem to be a consensus. Some sources say that meth causes permanent damage to the brain, while others are a little more hopeful and say some important brain functions might recover.

I used meth about fifteen times, which I gather isn't a lot in comparison to other meth users but is still a considerable amount. For a while I have felt paranoid and anxious and it has been more difficult to perform daily tasks and just generally think straight. Also, things I used to enjoy are not really that enjoyable anymore.

My question is, will I be able to have my brain back? If so, how much of it? Will I ever go back to being my old self?

I have become interested in trying LSD. But I am worried about what the side effects are and the consequences later in life. I only want to try and have no real need to continue, or desire to, for that matter. I am just really curious. What could happen to me? And do you know where one might find such drugs?

I originally took a muscle relaxer because I was experiencing very bad back pain and could not sleep. I was not prescribed the muscle relaxers. My friend suggested I take one of hers. So I did, and now I will take one sometimes before bed if I can't fall asleep or if I want to actually just relax. It makes me just want to sleep, and I feel really calm after taking one. Is this bad that I take them for this reason? What are the side effects? Is it harmful?

If you have little resources (i.e., money) left, can you get some help in drug rehabilitation centers?

I have a very addictive personality. Fortunately, I am married and have a family and because of the added responsibility of taking care of my family I stay away from a lot of the harmful vices. However, for some stupid reason I decided to try out nicorette. I quit smoking about 12 years ago and thought I would just try out nicorette to see if I could get a buzz. Well two years later I am totally hooked on the stuff and wondering if I should start smoking/chew/patch to get off the stuff. How bad is nicorette for you and is it better than smoking?

I am an ex-hardcore drug user — speed and cocaine to heroin — with 25 months of sobriety from drugs and alcohol. Now that I do not go out to clubs or party, I am finding difficulty in relationships.

Women do not understand why I do not drink. When they ask, I tell them where drugs and alcohol have gotten me in the past. This always seems to scare them off.

I feel guilty not telling them that I used to be an intravenous drug user, but when they ask about the tattoo on my arm that symbolizes a promise to myself never to inject again. I am honest about what it stands for. I never shared needles, I have been tested for AIDS/Hep-C and all of the tests have returned negative.

I am having difficulty finding someone that understands.

I have been taking between 5 and 10 mgs of methadone daily. I cannot seem to stop. Every time I try, I get very, very depressed and experience abdominal pain, chills, hot flashes, and sleeplessness. The depression and tremendous anxiety are intolerable and I end up taking more to avoid it. Question: Am I harming my body and/or mind with this stuff? How can I get off without the horrible feelings?

I have just realized that I am not able to handle alcohol. Whenever I go to a bar or a club, I drink to excess. I do not have any urge to drink. However, when I am in a club or a bar, the same thing happens: I drink too much! This is making me think that I am an alcoholic. My question is: Where can I go for help? Thanks.

I want to thank you and Columbia for this wonderful service! I have been browsing your archives for some help, here is the situation: I want to know what I can do to support my significant other when he is released from Drug Rehabilitation. Please help me!

My friend and I snorted a 10 bag each of heroin. Our heads began to feel heavy after ten minutes. Soon we entered into a dream world in which we hallucinated heavily. We talked to people who did not exist and we were very confused. I could not remember anything about who I was. I only remember certain parts of the four-hour trip that followed but I felt like I was on mushrooms for about two days. We could not read for that amount of time (nothing was in focus). What do you think we took? PCP? Bad synthetic heroin?

1) I found a white powder in my friend's car and I think it might be cocaine. I'm not sure if it is or not. I don't know if I should confront him with it or what I should do. I don't want to see my friend get hurt, but if I'm wrong, I don't want to falsely accuse him of something like this. How should I go about handling the situation?

2) I am a first-year business student and have a little sister who is a junior. I think she is doing cocaine because I found some "paraphernalia" in her room last week. What can I do without damaging my relationship with her?

What can I say to prevent someone from drunk driving?

My friend recently told me that she has a serious blow problem. She lives with her boyfriend and she said that all they do is work, sleep, and blow. By telling me this I understand that she has taken some very important steps into wanting to get better, but I'm completely useless in trying to help because I just don't know enough about the drug and rehab and ways to support her.

So far I've made the suggestion that she come spend some time with me and away from home so that the reminder of it is lessened, I can prevent her from bringing it in, and can try and keep her occupied to take her mind off it. What else can you suggest?

I have two concerns:

My boyfriend claims psychedelics open your mind to new ideas/perspectives and help you experience the "spiritual world." I maintain that anything you see or think is just a result from a brain overloaded on chemicals. However, I am beginning to feel closed-minded, and I would like to have your opinion on psychedelics — are they beneficial if used for a one-time experience, and will they immediately/permanently alter the way I view the world and myself? Given that I have doubts, should I even try anything this mind-altering? I have read your answers pertaining to short-/long-term effects, but I wanted to know if there was any actual evidence of the beneficial effects.

(1) I have a daughter who just joined AA. She has a drinking problem. What are our responsibilities to her as a husband, father, mother?

(2) Should any alcohol be kept in her house or our house (we are the parents) when she is around?

(3) It has been said that alcoholism runs in families — is this true? Does it seem to skip generations? If so, why?

I know that it is extremely dangerous to mix viagra (or other ED drugs) and poppers (amyl nitrate), and that one should wait for 24 hours after using viagra (to let it get out of your system) before using poppers. My question is what is the waiting period after using poppers before it is safe to use viagra? In other words, how long before the physiological effects of poppers wear off?

A couple of questions for you: what are the long-term side effects of one abusing prescription painkillers, such as Vicodin? What advice can you give to someone who has gotten off of them to help them stay off???

What is "gaming addiction"? Is it a real thing? I can play some games, like World of Warcraft or League of Legends, for a whole day, and I've sunk 150+ hours into RPGs. How many hours in front of a screen are too many?

I've recently dropped acid about 5 times a week for oh... about 3 months now. I have grown mentally and spiritually in ways unimaginable. But friends tell me I am in a false reality now; this brings me off my trip although I now only trip mentally (without the drug). In your opinion, has acid hurt me or helped bring my level of consciousness to a higher level? Am I reaching a state of Nirvana or am I simply a burn out? Please answer this question... I haven't the gall to ask anyone else.

The new acid like synthetic club drug "Foxy" has caught the attention of a few of my friends and I am wondering what kind of high it is — compared to LSD — and what kinds of damage it does to the brain?

I'm a college student who is struggling with the decision on when to see a doctor for treatment with my depression symptoms. I believe that I need to get treated for depression, but I'm just as scared about not getting treatment as I am about starting antidepressant drugs in my current lifestyle. As far as I can tell, I'm exhibiting the classic symptoms of depression, and have been for a while — frequent crying fits, days where I lose all motivation, and sometimes, even thoughts of suicide. But I drink frequently, almost every weekend, and use marijuana occasionally, and I am quite unsettled by the possible interactions between antidepressants and these other substances. In my day to day life I do very well — I hold a good GPA, have good relationships and a good social life, function well most of the time, and stay in shape for sports. I don't intend to change my lifestyle significantly to make room for depression treatment. But when do I need to get help? I don't want to force an unnecessary change on myself, but I don't want to put myself in danger from depression, or even worse, from the drug interactions between antidepressants and alcohol or weed. What is the tipping point?