I have two friends who were recently diagnosed with depression. They were both prescribed Prozac by their respective doctors. Both of them are heavy marijuana users and both failed to mention that to their doctors. One has been on Prozac for two months and the other for six weeks. I have noticed that their behavior has become strange: mood swings, paranoia, oversleeping, fatigue. They continue taking their Prozac (20 mg a day) and continue smoking pot. I am afraid that there might be some negative interaction between the substances, one being an antidepressant and the other a depressant. Can you provide some insight?

I have a friend at school who quit smoking last year in January, and went back to it in October. I have no idea why, and he also started doing other drugs, such as smoking blunts, doing ecstasy, and taking steroids. The drug that I am worried about him doing the most is ecstasy, because it's a dangerous drug. Also, he is always talking about doing drugs. How can I help him? I still want him to be my friend. Please help. This is serious.

I used to be a heavy ecstasy user and now am clean from ecstasy. I find I can't ejaculate. Alice, I guess my question is would the ecstasy have affected me sexually, so that I can't ejaculate when I'm having sex?

I am a teenage girl currently taking Adderall (20 mg) to treat my ADHD. My question: does taking this medication affect sexual wantings or behavior? I am supposed to start taking it at 7:00am so it will wear out at about 9:00 or 9:30pm. Since I go out later at night, my medicine is usually worn off before I engage in any kind of sexual activity. But sometimes on weekends I wake up late and have to take it at later times such as 12:00 or 1:00pm. Since then it will not wear off until after I go out, would being on Adderall affect my sexual behavior? I feel like I am less "horny" when on Adderall and sex is worse because of the lack of my desires. Does this have anything to do with my medicine or is it just a coincidence?

I have a huge dilemma. I have an addiction to a certain drug that has turned my life upside down. That drug is crack cocaine. The worst part about it is that nobody knows this but me. Nobody knows that right now, my life is on the brink. How do you express this problem to people who don't even have a clue as to what you are dealing with? How do you reach out to the people who you love and trust when you are so ashamed of the truth? One thing that I do know is that I'd better do something fast because if I don't, I will lose my fight with life. HELP!!