Can Reye's syndrome cause chemical imbalances later in life? My mother had it as a teenager and has really bad mood swings and possible hypochondria and my aunt and I are trying to figure out if having Reye's syndrome could be the cause for some of it.

Whenever I am in a very stressful situation such as an approaching big deadline, my body gets unusually tired and sleepy regardless of how much rest I get. I sleep well but it never seems to be enough. Why do I get so sleepy and what can I do to prevent this change when stressful situations approach?

1) My boyfriend, who I have been dating for a while now, says that he is fat and I don't think he is. He is built, but he isn't fat. And he talks about it all the time, and I just don't know what to say to him. He said that when he used to talk with his other girlfriend about it, that she would say, "well, go on a diet," and he said that made him feel like he was fat. And I don't want to hurt his feelings, but I know that by losing weight, he would feel better about himself. But I like him for who he is and how he looks. But what should I say to him when he says things like he is fat, do you think I'm fat, etc.?

2) I am a male, 24 years old, height 5'10", and currently I weigh 143 lbs... When I was 17 or so, I weighed a hefty 190 lbs... at that time, that really had a negative effect on my self image, and now at 143, I still don't think I'm thin enough... I have lost all my weight 100 percent through diet and running about 20 miles/week... but I don't eat enough and I always worry before I leave home if I "look ok"? Do I have serious issues?!?

You have an excellent service and give great advice. That is why I feel comfortable asking you this question. About three weeks ago, a group of my friends and I went out to a movie and then a club where we each had some alcohol. After the club, we went back to a friend's room where the group gradually dispersed until there was only myself, two male friends, and one female friend. We began to play sex games. Eventually, we all were naked, on my friend's bed. The female of the group was the center of our activity. She seemed to want it and even encouraged what the three of us started doing to her.

Although we all were tipsy, it was a great sexual experience for all of us, or so I thought. My two male friends have no problem with what happened. The only thing is that my female friend won't speak to us or return any of our calls. I saw her walking down the street the other day and tried to talk to her, but she wouldn't even raise her head to look me in the eye. Do you have any idea what is wrong? Could my friend feel that she was raped? I want to apologize, but I'm not sure what to do.

Every time I have an orgasm (alone or with a partner) I have intense feelings of guilt. I was not brought up in a religious household and was never told to "wait until marriage". I've been in long term relationships with all my sexual partners so it's not like I feel guilty for sleeping around. It's getting to the point where I'm not enjoying sex anymore because I dread the feelings I have after an orgasm. Is this normal?

I have a problem that is really uncomfortable for me to deal with, but I'm embarrassed to ask anyone if they have had the same experience. Whenever I take an exam, I sometimes ejaculate in my underwear. I think it may be some sort of stress reaction. Once it's over, I feel very calm and can continue on. Is something wrong, and how common is this? What should I do?