My granddad has been an alcoholic for ages — way before I was born. I am really worried about my granddad’s drinking. My father doesn't like me to see him when he is drunk, but that is kind of hard. What are the best groups for alcoholics? And most importantly, what should I do?

I'm curious about drugs — in particular what happens when you chemically combine methamphetamine and PCP and how it might affect the body. Some places online say they're the same thing, but I'm not so sure.

My uncle shoots heroin. My father used to do cocaine. My moms' (both of them) used to smoke weed with their friends when I was eight. I smoked weed when I was twelve. I sold weed at 14.

I don't want to continue in the vein of my addictive family (no pun intended). How hereditary is addiction? What measures can I take to avoid falling into the same hazy trap of my family members?

I know all the effects smoking has on the body, but nobody seems to have information on what it does to your sex life. What are the effects, like dryness, de-sensitivity in areas, etc? If I quit, would sex be better?

I am a freshman on a collegiate varsity sports team. Team gatherings, when we are not practicing, usually consist of excessive drinking with and without drinking games. I did not drink in high school and when I tried drinking with the team it made me feel really sick. I want to bond with my teammates (they are really great when not drunk) but I don't know how because if I am the only guy in the room not drinking I can't play drinking games with them, discuss favorite types of alcohol, or even carry on a real conversation because at a certain point in the night they stop forming coherent sentences. I need to be friends with this group of people but I would like to do so in a way that allows me to remember the night in the morning. Is this possible? What should I do?

While I don't really approve of their lifestyle (why devote six days a week to practice only to reduce your performance with alcohol?), I make no moral judgement. I don't want to change their way of doing things, I just want them to respect my way.

On "big nights out" (about once a month) friends of mine "plug" ecstasy tablets — by which I mean they each stick one up their butt instead of swallowing.

They claim that is a "safer" way to ingest E because it bypasses the liver and goes right into the bloodstream. They also claim the effects are heightened.

I have been tempted to try this method as they swear by it, but thought I'd get your opinion first — are there any potential side effects to plugging? Is it really a "safer" way to use E?

Recently, I have heard about a new hallucinogen available called salvia dinorium. Some of my friends have tried it and they tell me it is an incredible experience and that when you hallucinate, you have the perception of being brought back in time. Before I even think about trying this, however, I would like to have a more precise idea of what the effects are and what the possible risks of taking salvia are.

I am curious about the effectiveness of ketamine for therapy and recovery of drug use in young people/teenager in depression and success rate.